Studies on analgesic effects and sites of oxymatrine-carbenoxolone sodium complex.
- Author:
Jun-Jun ZHOU
1
;
Yuan-Xu JIANG
;
Shao-Ju JIN
;
Li-Jun TAO
;
Li-Jun LIU
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; Analgesics; administration & dosage; chemistry; pharmacology; therapeutic use; Animals; Carbenoxolone; administration & dosage; chemistry; pharmacology; therapeutic use; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred ICR; Pain; drug therapy; Quinolizines; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(7):822-824
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the analgesic effects and sites of oxymatrine-carbenoxolone sodium complex (OCSC).
METHODAdopting formalin test, warm water tail-flick test and intracerebroventricularly (icv) injection to observe the analgesic effects of OCSC in mice.
RESULTIntraperitoneally injecting (ip) OCSC (75, 150 mg x kg(-1)) remarkedly inhibited the pain of mice in the formalin test and prolonged latent phases of tail-shrinking of mice, icy OCSC (1.875, 3.75, 7.5 mg x kg(-1)) significantly prolonged latent phases of tail-shrinking of mice, it had dose-dependent effect with concentration.
CONCLUSIONThe result indicated that OCSC has obvious analgesic effects and its mechanism may be involved in central nervous system (CNS).
