Preparation and evaluation in vivo of Scutellaria thermosensitive gel.
- Author:
Cheng-Jun SONG
1
;
Ying WANG
;
Chun-Yan WANG
;
Lei TIAN
;
Yan-Jun LIU
;
Rui-Bin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; chemistry; metabolism; toxicity; Eye; drug effects; Female; Gels; Male; Ophthalmic Solutions; metabolism; Poloxamer; chemistry; Rabbits; Scutellaria; chemistry; metabolism; toxicity; Sensitivity and Specificity; Time Factors; Transition Temperature
- From: China Journal of Chinese Materia Medica 2008;33(6):628-631
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study scutellaria thermosensitive gel in situ.
METHODThe phase transition temperature of gel with various concentration polymer solutions was studied by using stirring method and the viscosity of gel was monitored under different temperatures. Eye irritation experiments were performed with rabbit. The duration of residence time in rabbit eyes of scutellaria thermosensitive gel was observed with 2% fluorescein.
RESULT20% poloxmar407 and 10% poloxmar 188 were suitable to scutellaria thermosen-sitive gel in situ. The results suggested that the scutellaria thermosensitive gel in situ based on poloxmar were nonirritant and retention time on the surface of eye was (150 +/- 8) min.
CONCLUSIONThe scutellaria thermosensitive gel in situ forms gel in eye and has longer release time than that of eye drops.
