OBJECTIVETo study the process of eliminating tannin with polyamide-adsorption for preparing Xinshao lyophilyzation.

METHODThe transfer rate of paeoniflorin, tannin examination, the test of the local stimulus and abnormal toxicity on mice were adopted as indexes to optimize the process of tannin adsorption and resolution of polyamide-adsorption, and the effect of eliminating tannin of polyamide-adsorption was compared with traditional methods.

RESULTThe effect of eliminating tannin with polyamide-adsorption was good, and the transfer rate of paeoniflorin with polyamide-adsorption was superior to the other methods. Furthermore, the abnormal toxicity decreased evidently and the security of the preparation was ensured.

CONCLUSIONThe method of polyamide-adsorption provides a useful reference to the technique of eliminating tannin in the traditional Chinese medicine injections.