Advances in research on G protein-coupled inward rectifier K(+) channel gene.
10.3881/j.issn.1000-503X.2012.04.023
- Author:
Yong-an KANG
1
;
Yan-rong HU
;
Nan-fang LI
Author Information
1. Medical College of Shihezi University, Shihezi, Xinjiang, China.
- Publication Type:Journal Article
- MeSH:
Atrial Fibrillation;
genetics;
G Protein-Coupled Inwardly-Rectifying Potassium Channels;
genetics;
Humans;
Metabolic Syndrome;
genetics
- From:
Acta Academiae Medicinae Sinicae
2012;34(4):426-430
- CountryChina
- Language:English
-
Abstract:
G protein-coupled inward rectifier K(+) channel 4(GIRK4) is a G protein-coupled inward rectifier potassium channel family member. Encoded by the KCNJ5, it is widely distributed in the mammalian heart, brain, and other tissues and organs. Recent studies have demonstrated that the abnormal expression of GIRK4 gene is associated with atrial fibrillation, and meanwhile may be closely related to obesity, metabolic syndrome, and many other clinical conditions. Further research on the role the GIRK4 gene in the pathophysiology of these clinical conditions will definitely facilitate their clinical diagnosis and treatment.
