Voxel-based Relaxometry of transverse relaxation rate with gradient echo R2(*) in patients with multiple system atrophy.
- Author:
Bo HOU
1
;
Hui YOU
;
Han WANG
;
Yan-ping ZHAO
;
Bo JIANG
;
Hong-yi SUN
;
Li-ying CUI
;
Feng FENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Female; Humans; Image Processing, Computer-Assisted; methods; Magnetic Resonance Imaging; Male; Middle Aged; Multiple System Atrophy; diagnosis; Sensitivity and Specificity
- From: Acta Academiae Medicinae Sinicae 2012;34(5):450-454
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the transverse relaxation rate with gradient echo R2(*) changes in patients with Parkinsonian variant of multiple system atrophy (MSA-P) with a voxel-based analysis of R2(*) map.
METHODSWhole brain structural images and multi-echo T2(*) weighted image were acquired in 27 patients with probable MSA-P and 24 healthy individuals. R2(*) maps of the MSA-P were compared with the controls by voxel-based methods.
RESULTCompared with the controls, MSA-P patients showed significant R2(*) decrease bilaterally in brain stem, cerebellar hemispheres, insular lobe, temporal lobes, caudate nucleus, and corpus callosum (P<0.005).
CONCLUSIONSR2(*) can reveal the significant brain involvements of MSA-P. The introduction of gradient echo may increase the sensitivity, although the susceptible artifact may interfere the detection efficiency of R2(*).
