Expression of Th17/Treg cell in patients with psoriasis arthritis and its clinical significance.

Author: Jin-guang CHEN ¹ ; Wei LAI ; Yu JIANG
Author Information

1. Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Publication Type:Journal Article
MeSH: Aged; Arthritis, Psoriatic; blood; immunology; Case-Control Studies; Female; Humans; Interleukin-17; blood; Male; Middle Aged; T-Lymphocytes, Regulatory; immunology; Th17 Cells; immunology; Transforming Growth Factor beta1; blood
From: Acta Academiae Medicinae Sinicae 2012;34(6):617-620
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the change of Th17/Treg cell in patients with psoriasis arthritis (PA) and its clinical significance.
METHODSThe levels of IL-17 and TGF-β1 were measured by enzyme-linked immunosorbent assay(ELISA) in PA patients (n=35) and healthy controls(n=30). The frequencies of Th17 and Treg in the peripheral blood were detected by flow cytometry.
RESULTSCompared with the healthy controls, Th17/Treg in peripheral blood were significantly increased (p<0.05), Th17-related cytokine IL-17 significantly increased (p<0.05), and TGF-β1 significantly decreased (p<0.05) in the PA patients.
CONCLUSIONTh17/Treg cell and the related cytokines IL-17 and TGF-β1 may be involved in the pathogenesis of PA.