Research advances in CKLF-like MARVEL transmembrane domain containing member 5.
10.3881/j.issn.1000-503X.2012.06.018
- Author:
Ye-qing YUAN
1
;
Yun-bei XIAO
;
Zhen-hua LIU
;
Xiao-wei ZHANG
;
Tao XU
;
Xiao-feng WANG
Author Information
1. Department of Urology, Peking University People's Hospital, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Chemokines;
genetics;
metabolism;
Humans;
MARVEL Domain-Containing Proteins;
genetics;
metabolism;
Neoplasms;
genetics;
metabolism;
Signal Transduction;
Tumor Suppressor Proteins;
genetics;
metabolism
- From:
Acta Academiae Medicinae Sinicae
2012;34(6):625-628
- CountryChina
- Language:Chinese
-
Abstract:
CKLF-like MARVEL transmembrane domain containing member(CMTM)is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM5 belongs to this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily(TM4SF). CMTM5 is broadly expressed in normal adult and fetal human tissues, but is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM5 may inhibit the proliferation, migration, and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear, CMTM5 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM5 may be a new target in the gene therapies for tumors, while further studies on CMTM5 and its anti-tumor mechanisms are warranted.
