Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas.
10.3881/j.issn.1000-503X.2012.06.021
- Author:
Feng CAI
1
;
Yi-dan ZHANG
;
Cong-xin DAI
;
Xiao-hai LIU
;
Ya-kun YANG
;
Yong YAO
;
Ren-zhi WANG
Author Information
1. Department of Neurosurgery, PUMC Hospital, CAMS and PUMC, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Growth Hormone-Secreting Pituitary Adenoma;
genetics;
Humans;
Intracellular Signaling Peptides and Proteins;
genetics;
Mutation;
Pituitary Neoplasms;
genetics
- From:
Acta Academiae Medicinae Sinicae
2012;34(6):640-644
- CountryChina
- Language:Chinese
-
Abstract:
Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.
