Expression of GIRK4 gene in kidney tissues of obese rat.
- Author:
Yong-an KANG
1
;
Yan-rong HU
;
Li GAO
;
Hai YANG
;
Nan-fang LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Gene Expression; Kidney; metabolism; Male; Obesity; genetics; metabolism; Potassium Channels, Inwardly Rectifying; genetics; metabolism; Rats
- From: Acta Academiae Medicinae Sinicae 2013;35(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of GIRK4 gene in the kidney tissues of obese rats.
METHODSObese rat models were established using diet-induced method. The GIRK4 protein expression in kidney tissues was determined in 20 obese rats and 10 normal rats using Western blot analysis.
RESULTSThe relative expression level of GIRK4 protein in the kidney tissues of obese rat (1.75±0.42) was significantly lower than that in normal rats (3.37±0.68, P<0.05).
CONCLUSIONGIRK4 has a low protein expression in the kidney tissues of obese rat.
