Roles of trichorhinophalangeal syndrome-1 gene in normal breast development and breast cancer.
10.3881/j.issn.1000-503X.2013.01.023
- Author:
Yi BAO
1
;
Zheng-xiang ZHONG
;
Ge CUI
;
Li GUO
;
Zhao-feng WANG
Author Information
1. Central Laboratory, the Second Hospital of Jiaxing, Jiaxing, Zhejiang, China. ybao2011@gmail.com
- Publication Type:Journal Article
- MeSH:
Breast Neoplasms;
genetics;
pathology;
DNA-Binding Proteins;
genetics;
Epithelial-Mesenchymal Transition;
Female;
GATA3 Transcription Factor;
genetics;
Humans;
Transcription Factors;
genetics
- From:
Acta Academiae Medicinae Sinicae
2013;35(1):121-124
- CountryChina
- Language:Chinese
-
Abstract:
GATA transcription factor family members have been found to involve in the growth and differentiation of mammary gland. Among them GATA-3 is regarded as the most critical regulator involving the tumorigenesis of breast cancer (BC). Recently, trichorhinophalangeal syndrome-1 gene (TRPS-1), a new GATA family member, has been identified to be highly prevalent in breast cancer. Compared with ER-negative breast cancer, the expression of TRPS-1 is higher in ER-positive breast cancer and was significantly correlates with estrogen receptor, progesterone receptor, and GATA-3, indicating it may serve as a ductal epithelial cell-specific regulator in the differentiation of breast ductal epithelial cells. Studies have shown that miR221/222 is able to downregulate the expression of an epithelial cell marker E-cadherin by targeting TRPS-1, resulting in mammary epithelial cells transition to mesenchymal cell (EMT). In addition, it has been well accepted that, and the Science and Technology Bureau of Jiaxing (2012AY1071-2)TRPS-1 plays a role in the differentiation of several other cell types including kidney nephric mesenchymal cells, columnar chondrocytes, and osteoclasts, indicating that TRPS-1 involves in mesenchymal-to-epithelial cell transition (MET). In this article, we summarize the roles of GATA transcription factor TRPS-1 in ductal epithelial cells and the roles of its gene and protein expressions in predicting the prognosis of breast cancer.
