Application of carbon nanoparticles in the laparoscopic sentinel lymph node detection in patients with cervical cancer.
- Author:
Kai-jiang LIU
1
;
Xin-wei LV
;
Qing LIU
;
Na-na HAN
;
Ming-fang RU
;
Juan WANG
;
Pei-quan LI
;
Wen-yu SHAO
Author Information
- Publication Type:Journal Article
- MeSH: Female; Humans; Laparoscopy; Lymphatic Metastasis; pathology; Nanoparticles; Predictive Value of Tests; Sensitivity and Specificity; Sentinel Lymph Node Biopsy; methods; Uterine Cervical Neoplasms; pathology
- From: Acta Academiae Medicinae Sinicae 2013;35(2):150-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of laparoscopic sentinel lymph node(SLN) detection with carbon nanoparticles tracer in cervical carcinoma.
METHODSTotally 21 patients with confirmed early cervical cancer were enrolled in this study.Before laparoscopic extended hysterectomy and pelvic lymphadenoetomy(and para-aortic lymphadenoectomy) , they were injected with carbon nanoparticles suspension injection tracer from cervical neck before surgery. The black-staining lymph nodes were cut as SLN under the laparoscope for routine pathological examination.
RESULTSOf these 21 patients, at least one SLN was successfully detected in 20 patients(95.24%) , and a total of 158 SLNs were detected.The conventional pathology results suggested that 5 patients(23.81%) had positive lymph nodes(n=16, including 14 in 4 patients) . The new approach showed a sensitivity of 80.0%(4/5) , accuracy of 100.0%(20/20) , and negative predictive value of 100.0%(16/16) for SLN detection.
CONCLUSIONLaparoscopic SLN detection with carbon nanoparticles tracer is a relative safe and sensitive method for in cervical carcinoma.
