Expression and clinical significance of circadian gene Per2 in non-small cell lung cancer.
- Author:
Chuang CHI
1
;
Zhi-feng HE
;
Yu LIU
;
Xiao-ming LIN
;
Cheng-chao SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Non-Small-Cell Lung; metabolism; pathology; surgery; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; metabolism; pathology; surgery; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Period Circadian Proteins; metabolism; Smoking
- From: Chinese Journal of Oncology 2013;35(2):129-131
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of Per2 in non-small cell lung cancer (NSCLC), and analyze its clinical significance.
METHODSThe expression of Per2 was determined in 60 NSCLC and 20 normal lung tissues by immunohistochemical assay, and the relationship between Per2 expression and clinicopathological features was analyzed.
RESULTSThe positive expression rates of Per2 in NSCLC and normal lung tissues were 71.7% and 95.0%, respectively (P < 0.05). The expression of Per2 in NSCLC was correlated with pathological differentiation and TNM stage (P < 0.05).
CONCLUSIONThe expression of Per2 in NSCLC is decreased. The negative expression of Per2 may contribute to the development and invasion in NSCLC.
