Analysis of the relationship between clinicopathological factors and lymph node matastasis of pancreatic adenocarcinoma.
- Author:
Jiang-jiao ZHOU
1
;
Yan-tao TIAN
;
Hao LIU
;
Jian-wei ZHANG
;
Cheng-feng WANG
;
Ping ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; immunology; pathology; surgery; Adult; Aged; Aged, 80 and over; CA-19-9 Antigen; metabolism; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplastic Cells, Circulating; Pancreatectomy; Pancreatic Neoplasms; immunology; pathology; surgery; Retrospective Studies; Tumor Burden
- From: Chinese Journal of Oncology 2013;35(2):132-134
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate retrospectively the relationship between clinicopathological factors and lymph node matastasis of pancreatic adenocarcinoma.
METHODSThe clinicopathological factors, including gender, age, preoperative CA-19-9 level etc. of 71 patients with pancreatic adenocarcinoma were summarized to analyze the relationship between those factors and lymph node matastasis.
RESULTSAmong the 71 cases, there were 49 males (69.0%) and 22 females (31.0%). Forty-eight were ≥ 60 (67.6%) and 23 were < 60 (32.4%) years old. Twenty patients had normal preoperative CA-19-9 level (28.2%) and 51 had elevated level (71.8%). The tumor in 43 (60.6%) cases located in the pancreatic head and neck, and 28 (39.4%) in the body and tail. The tumors in 8 patients were well-differentiated (11.3%), 27 were moderately differentiated (38.0%), and 36 were poorly differentiated (50.7%). The maximum diameter of the tumor was ≤ 2 cm in 11 cases (15.5%), 2 - 5 cm in 45 cases (63.4%), and > 5 cm in 15 cases (21.1%). Ten patients had tumor confined to the pancreas (14.1%), and 61 invaded peripancreatic tissues (85.9%). Vascular tumor thrombus was found in 48 cases (67.6%), and 23 cases were absent (32.4%). Thirty-six cases had lymph node matastasis (50.7%). Univariate chi-square test revealed that differentiation and range of local infiltration were significantly associated with lymph node meatstasis (P < 0.05). Multivariate logistic regression analysis also showed that differentiation and range of local infiltration were significantly associated with lymph node meatstasis (P < 0.05).
CONCLUSIONSThe differentiation of tumor and range of local infiltration of pancreatic adenocarcinoma are significantly associated with lymph node metastasis. There is no significant relationship of location of the tumor, maximum diameter, presence or absence of vascular tumor thrombus with lymph node metastasis. Therefore, special attention should be paid to lymph node dissection in cases with a poorly differentiated pancreatic adenocarcinoma invading into peripancreatic tissues.
