Analysis of prognostic factors after radical resection in 628 patients with stage II or III colon cancer.
- Author:
Qiong QIN
1
;
Lin YANG
;
Ai-ping ZHOU
;
Yong-kun SUN
;
Yan SONG
;
Feng DU
;
Jin-wan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Tumor-Associated, Carbohydrate; metabolism; Carcinoembryonic Antigen; metabolism; Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms; drug therapy; metabolism; pathology; surgery; Disease-Free Survival; Female; Follow-Up Studies; Humans; Liver Neoplasms; secondary; Lung Neoplasms; secondary; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Proportional Hazards Models; Retrospective Studies; Survival Rate; Young Adult
- From: Chinese Journal of Oncology 2013;35(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the clinicopathologic factors related to recurrence and metastasis of stage II or III colon cancer after radical resection.
METHODSThe clinical and pathological data of 628 patients with stage II or III colon cancer after radical resection from Jan. 2005 to Dec. 2008 in our hospital were retrospectively reviewed and analyzed.
RESULTSThe overall recurrence and metastasis rate was 28.5% (179/628). The 5-year disease-free survival (DFS) rate was 70.3% and 5-year overall survival (OS) rate was 78.5%. Univariate analysis showed that age, smoking intensity, depth of tumor invasion, lymph node metastasis, TNM stage, gross classification, histological differentiation, blood vessel tumor embolus, tumor gross pathology, multiple primary tumors, preoperative and postoperative serum concentration of CEA and CA19-9, and the regimen of adjuvant chemotherapy were correlated to recurrence and metastasis of colon cancer after radical resection. Multivariate analysis showed that regional lymph node metastasis, TNM stage, the regimen of postoperative adjuvant chemotherapy, and preoperative serum concentration of CEA and CA19-9 were independent factors affecting the prognosis of colon cancer patients.
CONCLUSIONRegional lymph node metastasis, TNM stage, elevated preoperative serum concentration of CEA and CA19-9, the regimen of postoperative adjuvant chemotherapy with single fluorouracil type drug are independent risk factors of recurrence and metastasis in patients with stage II-III colon cancer after radical resection.
