Association of genetic variantions of circadian clock genes and risk of breast cancer.
- Author:
Wen-miao WANG
1
;
Peng YUAN
;
Jia-yu WANG
;
Fei MA
;
Ying FAN
;
Qing LI
;
Pin ZHANG
;
Bing-he XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Biomarkers, Tumor; genetics; Breast Neoplasms; genetics; CLOCK Proteins; genetics; Carcinoma, Ductal, Breast; genetics; Case-Control Studies; Female; Genetic Variation; Humans; Period Circadian Proteins; genetics; Polymorphism, Single Nucleotide; Risk Factors
- From: Chinese Journal of Oncology 2013;35(3):236-239
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between genetic variantions of circadian clock genes and risk of breast cancer.
METHODSA case-control study including 406 breast cancer patients and 412 controls was conducted and genes Clock (rs2070062) and Per2 (rs2304672, rs2304669, rs934945) were genotyped by TaqMan real-time PCR. Unconditional logistic regression model was used to analyze the association between the genetic polymorphisms and breast cancer.
RESULTSIndividuals with the rs2304669-TT genotype showed significantly increased breast cancer risk with the OR of 2.33 when compared with the individuals with rs2304669-CC and CT genotypes (P = 0.001). In addition, the three haplotypes containing the risk T allele of rs2304669 were identified to be associated with increased breast cancer risk. However, it was found that rs2304672, rs2070062 and rs934945 polymorphisms were not related with breast cancer risk.
CONCLUSIONSThe locus rs2304669 on Per2 gene is associated with breast cancer risk. Genetic variation of circadian clock genes may increase the susceptibility to breast cancer. Therefore, it may become an important biomarker of susceptibility to breast cancer.
