A missense SNP in the codon of ADD1 phosphorylation site associated with non-cardia gastric cancer susceptibility in a Chinese population.
- Author:
Meng-han WANG
1
;
Jiang CHANG
;
Dian-ke YU
;
Wen TAN
;
Dong-xin LIN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Asian Continental Ancestry Group; genetics; Calmodulin-Binding Proteins; genetics; Codon; Female; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Middle Aged; Mutation, Missense; Odds Ratio; Phosphorylation; Polymorphism, Single Nucleotide; Stomach Neoplasms; ethnology; genetics
- From: Chinese Journal of Oncology 2013;35(4):311-314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study investigated the association between a missense SNP in the codon of ADD1 phosphorylation site and the susceptibility of non-cardia gastric cancer in a Chinese population.
METHODSPhosphoSitePlus and dbSNP database were combined to discover missense SNPs in the codon of phosphorylation site. Then, we genotyped the missense SNP in 1, 998 cases with non-cardia gastric cancer and 2, 008 cancer-free controls of Chinese descent. Analysis was conducted by using Logistic model adjusted by gender and age.
RESULTSThe rs4963 in the codon of ADD1 phosphorylation site was found. The frequencies of the 3 rs4963 genotypes, CC, CG, GG, among controls were 25.2%, 50.4%, and 24.4%, respectively, among patients were 20.1%, 50.6%, and 29.3%, respectively. Compared with CC genotype, the rs4963 CG genotype and GG genotype significantly increased the risk of non-cardia gastric cancer with the odds ratios being 1.24 (95%CI: 1.06 ∼ 1.46, P = 0.008) and 1.49 (95%CI: 1.25 ∼ 1.78, P < 0.001), respectively.
CONCLUSIONSFnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer.
