Advancement in the research of the role of macrophages in wound healing.
- Author:
Liang XUE
1
;
Xu-sheng LIU
Author Information
1. Department of Burns, the First Hospital Affiliated to Zhongshan University, Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Macrophages;
immunology;
Wound Healing;
immunology
- From:
Chinese Journal of Burns
2013;29(1):62-64
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages play important roles in all stages of wound healing. Changes in micro-environment leads to transformation of macrophages type I and type II, thereby playing a role in wound healing. During the early inflammatory phase, type I macrophages exert pro-inflammatory function such as antigen-presenting, phagocytosis, and the production of inflammatory cytokines and growth factors. While during the wound healing phase, macrophages were transformed into type II, which stimulate the proliferation of fibroblasts, keratinocytes, and endothelial cells by expressing growth factors. This results in the formation of granulation tissue, angiogenesis, and the formation of ECM, so as to promote wound healing. This review summarizes the function and change in phenotype of macrophages in different stages of wound healing.
