Advances in the research of the role of MicroRNAs in wound healing.
- Author:
Pu NING
1
;
De-wu LIU
2
Author Information
1. Department of Surgery, Wuhan City Hospital NO.3, Wuhan 430060, China.
2. Department of Surgery, Tongren Hospital of Wuhan University, Wuhan 430060, China. Email: dewuliu@126.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
MicroRNAs;
Wound Healing;
genetics
- From:
Chinese Journal of Burns
2013;29(4):374-377
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs are endogenous noncoding RNA molecules with 19-22 nucleotides in length. MicroRNAs can post-transcriptionally regulate gene and (or) protein expression by binding to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. As a huge family that regulates gene expression, microRNAs has recently been shown to not only participate in the normal healing processes of wounds but also closely related to pathologic wound healing, and formation of hypertrophic scars and keloids. This review focuses on the biogenesis of microRNA and its role in wound healing.
