Expression of FoxO3a in patients with acute myeloid leukemia and its clinical significance.
10.7534/j.issn.1009-2137.2013.04.007
- Author:
Jiang-Ning ZHAO
1
,
2
;
Quan-Yi LU
;
Xiao-Qing NIU
;
Peng ZHANG
;
Zhao WANG
;
Jin-Zong LIN
;
Yan-Hong ZHUANG
;
Jing-Yuan LU
Author Information
1. Department of Hematology, Zhongshan Hospital of Xiamen University, Xiamen 361004, Fujian Province, China
2. Department of Hematology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Bone Marrow Cells;
metabolism;
Case-Control Studies;
Child;
Female;
Forkhead Box Protein O3;
Forkhead Transcription Factors;
metabolism;
Humans;
Leukemia, Myeloid, Acute;
diagnosis;
metabolism;
Male;
Middle Aged;
Oncogene Proteins;
metabolism;
Prognosis;
Remission Induction;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(4):847-850
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the expression and clinical significance of forkhead box protein O3a (FoxO3a) in the patients with acute myeloid leukemia (AML). Western blot was used to detect the FoxO3a protein expression in bone marrow samples from 44 newly diagnosed AML patients and 5 healthy donors. Additionally, 14 patients' samples were reevaluated when they got complete remission (CR). The results showed that FoxO3a expression (FoxO3a/β-actin 0.43 ± 0.19) in newly diagnosed AML patients was much higher than that in healthy donors (FoxO3a/β-actin 0.19 ± 0.06) (P < 0.001). The FoxO3a level was down-regulated when CR was got and there was not significant difference between patients in CR and healthy donors (P > 0.10). The correlation analysis showed that the level of FoxO3a expression positively correlated with the white blood cell count of AML patients at the time of diagnosis. Although FoxO3a expression did not positively correlate with the CR rate, the higher FoxO3a expression in AML patients showed a shorter remission duration. It is concluded that FoxO3a may be a oncoprotein in AML, and the high FoxO3a expression is associated with poor prognosis.
