Effect of cucurmosin on chronic myeloid leukemia K562 cell line.
10.7534/j.issn.1009-2137.2013.04.015
- Author:
Ting-Bo LIU
1
;
Hui-Li LIU
;
Jie-Ming XIE
;
Jian-Da HU
Author Information
1. Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China (E-mail: liutb@medmail.com).
- Publication Type:Journal Article
- MeSH:
Animals;
Female;
Humans;
K562 Cells;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
drug therapy;
pathology;
Mice;
Mice, Inbred NOD;
Mice, SCID;
Plant Proteins;
pharmacology;
Xenograft Model Antitumor Assays
- From:
Journal of Experimental Hematology
2013;21(4):891-894
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the antitumor effect of pumpkin protein (cucurmosin, CUS) on subcutaneous transplant tumor in chronic myeloid leukemia K562 cell-NOD/SCID mice and leukemia model. The subcutaneous transplant tumor in K562-NOD/SCID mice and leukemia model were established; using two models, the antitumor activity of CUS in mice was evaluated. The results indicated that the inhibitory rate of 0.5 mg/kg and 1 mg/kg CUS on subcutaneous transplant tumor were 53.45% and 59.43% respectively; survival time of mice received 0.25 mg/kg and 0.5 mg/kg CUS was 39.8 ± 5.5 d and 43.4 ± 6.6 d, antitumor rate was 24.9% and 36% respectively. It is concluded that CUS has significant inhibitory effect on mice with CML cell line K562.
