Analysis of CD4(+) T cell function in patients suffered from pulmonary infection in the early phase after haploidentical hematopoietic stem cell transplantation.
10.7534/j.issn.1009-2137.2013.04.035
- Author:
Li DING
1
,
2
;
Xiao-Li ZHENG
;
Lei DONG
;
Dong-Mei HAN
;
Heng ZHU
;
Hong-Min YAN
;
Zi-Kuan GUO
;
Heng-Xiang WANG
;
Chu-Tse WU
Author Information
1. Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850, China
2. Department of Hematoloyg, General Hospital of Chinese Air Force, Beijing 100042, China.
- Publication Type:Journal Article
- MeSH:
Adenosine Triphosphate;
analysis;
Adolescent;
Adult;
CD4-Positive T-Lymphocytes;
immunology;
metabolism;
Child;
Female;
Hematopoietic Stem Cell Transplantation;
Humans;
Male;
Middle Aged;
Pneumonia;
immunology;
pathology;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(4):995-998
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the immune state of the patients suffered from pulmonary infection within 6 months after haploidentical hematopoietic stem cell transplantation (hi-HSCT). Adenosine triphosphate (ATP) value in CD4(+) T cells was measured by ImmuKnow method to assess the function of the lymphocytes in peripheral blood of 25 patients at 6 months after hi-HSCT. The results showed that the ATP level in CD4(+) T cells of the patients suffered from pulmonary infection was (179.88 ± 65.41) ng/ml before transplantation, (172.69 ± 118.81) ng/ml at 1 month, (218.15 ± 124.26) ng/ml at 3 months, (313.42 ± 116.29) ng/ml at 6 months after transplantation. The ATP level in CD4(+) T cells of the patients without pulmonary infection was (210.44 ± 94.71) ng/ml before transplantation, and decreased to (193.66 ± 133.69) ng/ml at 1 month and increased gradually to (355.02 ± 43.38) ng/ml at 3 months, (355.73 ± 93.85) ng/ml at 6 months after transplantation. It is concluded that the low ATP value in CD4(+) T cells in patients prior and post hi-HSCT may suggest probability of occurrence for infections, ATP value in CD4(+) T cells may be used as a reference indicator for clinical empirical use of antibiotics.
