Function of mTORC2 and its roles in hematological malignancies.
10.7534/j.issn.1009-2137.2013.04.048
- Author:
Hui-Dong GUO
1
;
Tao CHENG
;
Wei-Ping YUAN
Author Information
1. State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Hematologic Neoplasms;
Humans;
Mechanistic Target of Rapamycin Complex 2;
Multiprotein Complexes;
Signal Transduction;
TOR Serine-Threonine Kinases
- From:
Journal of Experimental Hematology
2013;21(4):1063-1068
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian target of rapamycin complex (mTORC) is an important center for regulating cellular growth, survival and metabolism. mTORC plays a vital role in maintenance of normal physiological activities and homeostasis in organism. According to protein components, mTORC can be divided into two distinct protein complexes: mTORC1 and mTORC2. The main protein components of mTORC2 include mTOR, Rictor, mLST8, Deptor, mSin1, Protor and Hsp70. By means of activating AKT, PKCα, SGK1 and so on, the mTORC regulates many vital activities:embryonic development, cytoskeletal reconstitution,cell migration and protein post-translational modification. The abnormality of mTORC2 signaling pathway has been confirmed to be associated with tumorigenesis, therefore, further understanding the components, functions and signalling pathway of mTORC2 will provide a new insights in developing targeted cancer therapy. In this review, the structure and signalling pathway of mTORC2 and its roles in hematological malignancies are discussed and summarised.
