Function of peripheral blood Th17 cells in patients with multiple myeloma.
10.7534/j.issn.1009-2137.2013.05.020
- Author:
Yao ZHANG
1
;
Lu-Xi SONG
;
Xi ZHANG
;
Chao XIAO
;
Chun-Kang CHANG
Author Information
1. Department of Hematology, Shanghai Jiaotong University Sixth people's Hospital, Shanghai 200233, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Female;
Humans;
Interleukin-17;
blood;
Interleukin-6;
blood;
Interleukins;
blood;
Male;
Middle Aged;
Multiple Myeloma;
blood;
Th17 Cells;
metabolism
- From:
Journal of Experimental Hematology
2013;21(5):1187-1189
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the effects of peripheral blood Th17 cells and their secreting IL-17, IL-21 in the occurrence and development of multiple myeloma (MM). A total of 55 patients with MM were divided into non-remission group (group A , n = 30), remission group (group B, n = 25); healthy volunteers were used as control group (group C , n = 30). The concentration of IL-17, IL-21 and IL-6 in the peripheral blood mononuclear cell (PBMNC) culture supernatant were determined with ELISA. The ratio of Th7 cells in PBMNC was determined by flow cytometry. The results showed that IL-17, IL-21 levels and ratio of Th17 cells in group A were much higher than those in group B and C (P < 0.05), IL-17, IL-21 and the ratio of Th17 cells between group B and group C were not significantly different (P > 0.05); IL-17 level in non-remission MM group positively correlated with IL-6 level (r = 0.782, P < 0.05), IL-21 level in non-remission MM group positively correlated with IL-6 level (r = 0.778, P < 0.05). It is concluded that Th17 cells as a initiating factor may be involved in the immune pathogenesis of MM patients, promoting the progress of the disease.
