Genetic susceptibility of single nucleotide polymorphism in MGMT to non-Hodgkin lymphoma.
- Author:
Fan YANG
1
;
Jing-yi SHI
;
Lan XU
;
Li-juan REN
;
Qiao-hua ZHANG
;
Wei-li ZHAO
;
Zhi-xiang SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; DNA Modification Methylases; genetics; DNA Repair Enzymes; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Lymphoma, Non-Hodgkin; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Tumor Suppressor Proteins; genetics; Young Adult
- From: Chinese Journal of Hematology 2009;30(9):622-625
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between five single nucleotide polymorphism loci in the MGMT, XPA, XPD and XPG genes and the prevalence of non-Hodgkin's lymphoma.
METHODSA case-control study of 73 lymphoma cases and 500 healthy controls was conducted and the Mass-ARRAY method was applied for detection of MGMT L84F, MGMT K178R, XPA TSS+62, XPD K751Q and XPG TSS+372.
RESULTSMGMT L84F (T allele) was associated with an increased risk of non-Hodgkin lymphoma (OR=2.085, 95%CI=1.069-4.068, P=0.029), mainly in B-cell lymphoma, of which the risk increased by 2.403-fold (OR=2.403, 95%CI=1.103-5.235, P=0.024). No statistically significance was found for MGMT K178R, XPA TSS+62, XPD K751Q and XPG TSS+372.
CONCLUSIONSingle nucleotide polymorphism in the MGMT gene may closely related to the occurrence of non-Hodgkin lymphoma, especially of B-cell subtype.
