Intracerebral infiltration by monoclonal plasmacytoid cells in Waldenstrom's macroglobulinemia: a case report and review of the literature.
- Author:
Jie-Ping LI
1
;
Xiao-Lin YIN
;
Pei-Yan KONG
;
Xing-Hua CHEN
;
Dong-Feng ZENG
;
Xi-Xi XIANG
;
Xian-Gui PENG
Author Information
- Publication Type:Case Reports
- MeSH: Brain; pathology; Humans; Male; Middle Aged; Neoplasm Invasiveness; Waldenstrom Macroglobulinemia; pathology
- From: Chinese Journal of Hematology 2009;30(10):672-674
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo sum up the clinical experience of the diagnosis and treatment of intracerebral infiltration by monoclonal plasmacytoid cells in Waldenstrom's macroglobulinemia(Bing-Neel syndrome).
METHODSThe clinical data of the diagnosis and treatment of a case of Bing-Neel syndrome was analyzed.
RESULTSA 56-year-old male was diagnosed as Waldenstrom's macroglobulinemia one year ago, and presented with persistent headache during the treatment period. Magnetic resonance imaging showed a high intensity area on T2-weighed images in the right frontal lobe which was well enhanced by gadolinium-diethylenetriaminepenta-acetic acid. Infiltration of neoplastic cells was confirmed by biopsy. Immunohistochemical examination showed that mature plasmacytoid cells in the cerebral parenchyma were immunoglobulin M positive.
CONCLUSIONInfiltration in CNS (Bing-Neel syndrome) is uncommon in Waldenstrom's macroglobulinemia. As there is no effective therapy for this Bing-Neel syndrome, combination of radiation and chemotherapy should be considered for this situation.
