Acute T cells lymphoblastic leukemia with a t(1;19)(q23;p13) and E2A-PBX1 in an adult: one case report and literature review.
- Author:
Guang-Sheng HE
1
;
Xu-Hui ZHANG
;
Li YAO
;
Ri ZHANG
;
Zi-Xing CHEN
;
De-Pei WU
;
Ai-Ning SUN
;
Zheng-Ming JIN
;
Hui-Ying QIU
;
Xiao-Hui HU
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Chromosomes, Human, Pair 1; genetics; Chromosomes, Human, Pair 19; genetics; Homeodomain Proteins; genetics; Humans; Karyotyping; Male; Oncogene Proteins, Fusion; genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; drug therapy; genetics; Translocation, Genetic
- From: Chinese Journal of Hematology 2009;30(10):675-677
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo report a case of T cell acute lymphoblastic leukemia (ALL) with t(1;19)(q23;pl3) and E2A-PBX1 fusion gene, which is a characteristic translocation of childhood B cell ALL (B-ALL).
METHODSThe chromosome, karyotype, immunophenotype and mRNA for fusion gene of the leukemic cells were examined by cytogenetic analysis, flow cytometry (FCM) and reverse transcriptase PCR (RT-PCR), respectively.
RESULTSThe cytogenetic karyotype of the patient was 47, XY, 9p+, 15p+, 17q-, der(19), t(1;19)(q23;pl3)\[5\]/46, XY\[15\], and E2A-PBX1 was positive. The leukemic cells expressed T cell markers. The patient was induced with hyper CVAD regimen (cyclophosphamide, vincristine, adriamycin, and dexamethasone), and achieved complete remission with normal cytogenetic karyotype 46 XY\[10\], and negative E2A-PBX1.
CONCLUSIONt(1;19)E2A-PBX1(+) can be implicated in adult T-ALL, besides childhood B-ALL.
