Combination of rabbit antithymocyte globulin plus cyclosporin A as first-line immunosuppressive therapy for the childhood with severe aplastic anemia..
- Author:
Li-Yuan LIU
1
;
Hui-Jun WANG
;
Li ZHANG
;
Li-Ping JING
;
Kang ZHOU
;
Dong-Lin YANG
;
Hong-Qiang LI
;
Qing-Guo LIU
;
Zhang-Song YAN
;
Yong-Ze LIU
;
Yu-Hong WU
;
Yu-Lin CHU
;
Feng-Kui ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Anemia, Aplastic; therapy; Animals; Antilymphocyte Serum; Cyclosporine; therapeutic use; Humans; Immunosuppressive Agents; therapeutic use; Rabbits; Treatment Outcome
- From: Chinese Journal of Hematology 2009;30(11):749-753
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyse the efficacy and side-effects of rabbit antithymocyte globulin (ATG) and cyclosporin A (CsA) as the first-line therapy for childhood severe aplastic anemia (SAA).
METHODSSeventy-one childhood SAA patients treated with rabbit ATG + CsA as first line therapy were retrospectively analysed.
RESULTSSeventy-one SAA patients, including 38 SAA and 33 very severe aplastic anemia (VSAA), were enrolled. The median age was 12 years. Of these patients, 3 died within 3 months after the immunosuppressive therapy (IST). The overall response rate was 67.6% (46/68) and the median time to transfusion independent was 53 days. Thirty-three patients (48.5%) obtained remission in 3 months after the IST and 45 (67.2%) in 6 months. The response rates were 57.7% (15/26), 56.5% (13/23) and 94.7% (18/19) for patients less than 10 years old, 10 - 15 year-old and 15 - 18 year-old, respectively. Sixty patients suffered from serum sickness on the IST. Three patients relapsed and another 3 unrespond patients received retreatment of IST, and one patient progressed to myelodysplastic syndromes (MDS).
CONCLUSIONRabbit ATG in combination with CsA as first line therapy for childhood SAA/VSAA can lead to overall response rate of 67.6% with minor adverse effects.
