Correlation between the change in liver enzymology and the severity of acute graft-versus-host disease..
- Author:
Xiao-Dong MO
1
;
Lan-Ping XU
;
Kai-Yan LIU
;
Dai-Hong LIU
;
Huan CHEN
;
Feng-Rong WANG
;
Xiao-Hui ZHANG
;
Wei HAN
;
Yu-Hong CHEN
;
Xiao-Jun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Graft vs Host Disease; Humans; Liver; Retrospective Studies
- From: Chinese Journal of Hematology 2009;30(12):816-820
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between the change of liver enzymes and the severity of acute graft-versus-host disease (aGVHD).
METHODSThe liver enzyme and severity of aGVHD in 82 patients were analyzed retrospectively.
RESULTSAmong the 82 aGVHD patients, 7 developed grade I (18.3%), 47 grade II (57.3%), 13 grade III (15.9%) and 7 grade IV (8.5%) aGVHD. The elevation of ALT, AST and ALP was found in 49 (59.8%), 36(43.9%) and 8(9.8%)patients respectively. Among these patients, 34 (69.4%) were ALT > 40 U/L, 18 (50%) AST > 40 U/L and 4 (50%) ALP > 132 U/L before the onset of aGVHD. The elevation of ALT and AST was more common and the peak value was significantly higher in patients with grade III-IV aGVHD than with grade I-II aGVHD, but those of ALP showed no difference between the two groups. Compared with the patients without ALT elevation, the proportion of severe aGVHD was higher in patients with ALT elevation.
CONCLUSIONSThe alteration of liver enzymology is common in aGVHD and its level is correlated with the severity of aGVHD. Liver enzymes, especially the ALT, may be used as a predictor of aGVHD.
