Stability of physical state on compound hawthorn dropping pills.
- Author:
Wei ZHANG
1
;
Hong-Yan CHEN
;
Jian-Lan JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Crataegus; chemistry; Drug Compounding; methods; Drug Stability; Drugs, Chinese Herbal; chemistry; Microscopy, Electron, Scanning; Solubility; Spectroscopy, Fourier Transform Infrared
- From: China Journal of Chinese Materia Medica 2008;33(21):2474-2478
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the stability of physical state with accelerate test and dropping in process before and after on compound hawthorn dropping pills.
METHODScanning electron microscope, TG-DTA, FT-IR and XRD were used.
RESULTThe active components presented amorphous, tiny crystal and molecular state in dropping pills, and it had no obvious reaction between PEG 4000 and active components. With time prolonging, a little of active components changed from amorphous state to tiny crystal or molecular state.
CONCLUSIONSolid dispersion improved the stability and dissolution of compound hawthorn dropping pills.
