Investigation on inhibition of HIV III B virus with extractions of Juglans regia.
- Author:
Zhao-Mei LIU
1
;
Rui-Xing WEN
;
Hong-Tao MA
;
Yi-Shu YANG
;
Xiao-Li WANG
;
Xiu-Hua LV
;
Ze-Lin LI
Author Information
- Publication Type:Journal Article
- MeSH: Cell Line; Drugs, Chinese Herbal; chemistry; pharmacology; HIV-1; drug effects; Humans; Juglans; chemistry; Plant Extracts; chemistry; pharmacology
- From: China Journal of Chinese Materia Medica 2008;33(21):2535-2538
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of anti-HIV III B virus with extractions from Juglans regia, so as to searching for the new and efficacious leading compound of AIDS therapy.
METHODPhytochemical and chromatographical techniques were used to isolate compounds from J. regia; MT4 cells and HIV III B virus were used to study the effect of anti-HIV activity in vitro. BIACORE 3000 molecule coupled equipment were used for the target research also.
RESULTTwo extractions (B&E) were isolated from J. regia which possess the effect of anti-HIV activity. Targets study found that extraction B could affected on HIV-1 gp-41 fusing protein and extraction E could affected on HIV-1 integrase respectively.
CONCLUSIONJ. regia is a traditional Chinese medicine with active anti-HIV activity and worth to be studied further.
