Phenolic acids from Arnebia euchroma mifepristone in anti-early pregnancy of SD rattus norvegicus.
- Author:
Li-Jun WANG
1
;
Xin-Yi ZHANG
;
Mao-Chuan LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Abortifacient Agents; chemistry; pharmacology; Animals; Boraginaceae; chemistry; Female; Hydroxybenzoates; chemistry; pharmacology; Male; Mifepristone; pharmacology; Pregnancy; drug effects; Progesterone; blood; Radioimmunoassay; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2008;33(20):2378-2381
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEObserving the effect of phenolic acids from Arnebia euchroma assist mifepristone in anti-early pregnancy of SD rattus norvegicus.
METHODFeed the SD rattus norvegicus with phenolic acids from A. euchroma during the 7 th to 9 th day, and then we observe the restaining rate of pregnancy. At the same time, we determine the progesterone level in blood serum in the ways of radioimmunoassay.
RESULT720 g x kg(-1) enolic aids from A. euchroma can markedly increase the restaining rate of pregnancy (P < 0.05) than that only mifepristone dose (8.0 g x kg(-1)). In addition, the number of everage still bith increase, however, to the pogesterone level in blood serum. It has little effect.
CONCLUSIONThe effect of phenolic acids from A. euchroma assist mifepristone in anti-early pregnancy of SD rattus norvegicus is clear, and it dosen't work in the ways of decreasing the pogesterone level.
