Effects of penetration enhancers on percutaneous permeability of geniposide in Xiao'er Ninhuang tuire cataplasms.
- Author:
Zhao-Hua SHI
1
;
Fu-Liang XIONG
;
Zhi-Jun HUANG
;
Deng-Ke XIONG
;
Qing-Hui ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Azepines; pharmacology; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; chemistry; In Vitro Techniques; Iridoids; chemistry; Pharmaceutical Vehicles; pharmacology; Propylene Glycol; pharmacology; Rats; Rats, Sprague-Dawley; Skin; drug effects; metabolism; Skin Absorption; drug effects
- From: China Journal of Chinese Materia Medica 2008;33(18):2061-2063
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the different permeation enhancers on the transdermal permeation of Xiao'er Niuhuang tuire cataplasms (XNTC).
METHODUsing improved franz-type diffusion cell with excised rat skin in vitro as the transdermal barrier, the content of permeated geniposide was determined by HPLC to study the kinetic parameters such as cumulative permeation quantity and permeation rate.
RESULTThe result showed that the process of penetrating of geniposide in XNTC through skin could be in accordance with zero-rade releasing equation and XNTC was stable during the course of experiment.
CONCLUSION5% Propylene glycol (PG)-azone (2:3) has the best permeation-enhancing effect, and the results provided a primary basis for the future research on Xiao'er Niuhuang tuire cataplasms.
