Studies on cyclodextrin inclusion complexes of Dragon's blood and its tablets preparation.
- Author:
Bin-Bin HAN
1
;
Hui-Na PEI
;
Hai-Song SUN
;
Quan-Kui NING
;
Yong REN
Author Information
- Publication Type:Journal Article
- MeSH: 2-Hydroxypropyl-beta-cyclodextrin; Cyclodextrins; chemistry; Drug Stability; Drugs, Chinese Herbal; chemistry; Plant Extracts; chemistry; Solubility; Tablets; chemistry; beta-Cyclodextrins; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(18):2066-2070
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the cyclodextrin inclusion complexes of Dragon's blood for improving the drug solubility and the preparation.
METHODThe inclusion complexes were prepared with beta-cyclodextrin, HP-beta-cyclodextrin, SBE-beta-cyclodextrin and confirmed by DTA. The activity of the inclusion complex was tested by animal experiments. Inclusion complexes tablets were prepared and the dissolution test was performed.
RESULTThe solubility of inclusion complexes was increased to 13. 75-168. 39 times. The activity of the inclusion complex was markedly improved, and dissolution rate was 78.69%.
CONCLUSIONThe cyclodextrin inclusion complexes of Dragon's blood have a good solubility, dissolution rate and pharmacological activity.
