Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats.
- Author:
Hao-Gang DUAN
1
;
Yu-Hui WEI
;
Bo-Xia LI
;
Dong-Mei ZHANG
;
Jin-Wen ZHANG
;
Xin-An WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; blood; drug therapy; metabolism; Drug Interactions; Drugs, Chinese Herbal; therapeutic use; Male; Metformin; blood; pharmacokinetics; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2008;33(18):2133-2139
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study effects of Yuquan pills on the pharmacokinetics process of metformin hydrochloride in diabetic rats.
METHODAfter administration Yuquan pills 7 day to the diabetic rats, the metformin hydrochloride was orally administrated, then the blood samples were collected at different time. The concentrations of metformin hydrochloride in plasma were determined by HPLC method and the pharmacokinetic parameters were calculated.
RESULTThe pharmacokinetic parameter Cmax of the controlling group and the testing group were respectively, 18.95, 21.76 mg x L(-1); t1/2 were 1,069.8, 1,767.4 min, respectively; CL/F were 0.013, 0.008 L x min(-1) x kg(-1); AUC were 10,042.1, 10,712.2 mg z L(-1) x min(-1) respectively.
CONCLUSIONThe pharmacokinetics process of metformin hydrochloride in diabetic rats fits one-compartment model. Yuquan pills has a significant effect on the pharmacokinetics of metformin hydrochloride in diabetic rats.
