Formulation optimization of controlled porosity osmotic-pump tablets of total paeony glycosides.
- Author:
Hui ZHANG
1
;
Wen-Ping WANG
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; methods; Drugs, Chinese Herbal; chemistry; Glycosides; chemistry; Osmotic Pressure; Paeonia; chemistry; Porosity; Tablets; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(19):2185-2187
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare controlled porosity osmotic-pump tablets of total paeony glycosides (TPG) and establish the relationship between formulation factors of membrane and drug release rate.
METHODUniform design was used to achieve the quantitative relationship between the release rate and formulation factors of membrane. Optimized prescription was calculated from the regression equation.
RESULTA significant correlation and a fine precision of the regession equation were obtained. Controlled porosity osmotic-pump tablets of TPG were prepared based on the calculations, and the drug release profile was in accord with zero-order kinetics (r = 0.9902).
CONCLUSIONUniform design is a convenient and efficient approach for formulation optimization of controlled porosity osmotic-pump tablets.
