Effect of pectins of different degree of esterification on in-vitro sophoridine release of hydrophilic matrix tablets containing total alkaloids of Sophora alopecuroides.
- Author:
Wen-Chang ZHAO
1
;
Hong-Zhu DENG
;
Li-Jun SONG
;
Yong-Heng HUANG
;
De-Hao HUANG
;
Hui YAN
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; Animals; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Colon; chemistry; Esterification; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Pectins; chemistry; Quinolizines; chemistry; Rats; Rats, Sprague-Dawley; Sophora; chemistry; Tablets; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(19):2188-2192
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare colon-targetting tablets of total alkaloids of Sophora alopecuroides and evaluate the effect of pectins of different degree of esterification (DE) on sophoridine release profiles in-vitro.
METHODWet granulation technique was employed to prepare petin-based matrix tablets, then tablets were coated the optimal formulation with Kollicoat MAE 30 DP based on the optimal formulation and analysed their release.
RESULTCoated formulation E could target total alkaloids of S. alopecuroides to colon and various DE of pectin exerted different effects on sophoridine release. The release of low DE pectin-based matrix tablets coating with Kollicoat MAE 30 DP approximatedly fitted zere-order eqution, which was erosion depended.
CONCLUSIONLow DE pectin-based matrix tablet coating with Kollicoat MAE 30 DP can deliver sophoridine to colon, hence improve the effectiveness of sophoridine.
