Study on drug release after arterial embolism with cisplain-loaded albumin microspheres in treating carcinoma of tongue.
- Author:
Hongwei LI
1
;
Yuming WEN
;
Changmei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Albumins; Antineoplastic Agents; administration & dosage; blood; Arteries; Carcinoma, Squamous Cell; drug therapy; Cisplatin; administration & dosage; blood; Delayed-Action Preparations; Drug Carriers; Female; Humans; Infusions, Intra-Arterial; Male; Microspheres; Middle Aged; Tongue; blood supply; Tongue Neoplasms; drug therapy
- From: West China Journal of Stomatology 2003;21(2):112-139
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe purpose of this study was to investigate the cisplatin release in peripheral blood and tumor tissue after cisplatin-loaded albumin microspheres (CDDP-AMS) were infused through lingual artery for treating carcinoma of tongue.
METHODSAnticancer agent cisplatin was encapsulated with biodegradable and non-antigenic albumin. The cisplatin-loaded albumin microspheres, which were 56.3 microns in diameter, were used for treating 7 patients with squamous carcinoma of tongue by infusing through lingual artery. The cisplatin in peripheral venous blood and carcinoma tissue were measured for analyzing the drug release in vivo.
RESULTSConcentration of the drug in peripheral venous blood increased to the highest level in 90 minutes after CDDP-AMS was infused through lingual arterial and still could be detected until 10th day. The cisplatin concentration in tumor tissue kept considerably stable and could be detected until 17 days.
CONCLUSIONCDDP-AMS had the effect of controlled release in vive. Effective and steady local drug concentration played the role of killing tumor cells, the low concentration in peripheral blood reduced the side effects of cisplatin to minimum as well. It is concluded that CDDP-AMS is a useful and recommendable method for treating the carcinoma of tongue.
