Pathologic diagnosis and differential diagnosis of pulmonary Langerhans' cell histiocytosis.

Author: Ji LI ¹ ; Hong-rui LIU ; Li-na GUO
Author Information

1. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Antigens, CD; analysis; Antigens, CD1; analysis; Antigens, Differentiation, Myelomonocytic; analysis; Child; Diagnosis, Differential; Female; Histiocytosis, Langerhans-Cell; diagnosis; metabolism; pathology; Humans; Langerhans Cells; chemistry; Lung; pathology; Male; S100 Proteins; analysis
From: Chinese Journal of Pathology 2004;33(2):109-112
CountryChina
Language:Chinese
Abstract:
OBJECTIVEMorphologic findings of pulmonary Langerhans' cell histiocytosis were analyzed in order to delineate diagnostic features.
METHODSH&E staining and immunohistochemical studies were performed on 7 cases of pulmonary Langerhans' cell histiocytosis.
RESULTSInfiltration by Langerhan's cells was obvious in all 7 cases. Inflammatory cell infiltrates, interstitial fibrosis and focal necrosis may also be seen. The cells expressed S-100 (7/7), CD68 (3/7), and CD1a (5/5).
CONCLUSIONSIn case there is radiologic suspicion of Langerhans' cell histiocytosis, pulmonary biopsy is strongly advised for a definitive diagnosis. S-100 and CD1a immunostaining is also helpful in this respect.