Sulfur dioxide-induced liver pathology.

Author: Jian-ying BAI ¹ ; Zi-qiang MENG
Author Information

1. Institute of Environmental Medicine and Toxicology, School of Life Science and Technology, Shanxi University, Taiyuan 030006, China.
Publication Type:Journal Article
MeSH: Administration, Inhalation; Animals; Hepatocytes; drug effects; pathology; Liver; drug effects; pathology; ultrastructure; Male; Mice; Microscopy, Electron; Sulfur Dioxide; administration & dosage; toxicity
From: Chinese Journal of Pathology 2004;33(2):155-157
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate effects of short-term sulfur dioxide inhalation to the liver.
METHODSHaematoxylin and eosin staining (HE) and transmission electron microscopy (TEM) were used to study the pathologic changes in mice liver after sulfur dioxide (SO(2)) inhalation.
RESULTSExposure to 56 mg/m(3), 112 mg/m(3) 168 mg/m(3) SO(2) caused increasingly severe liver injuries, as detected by HE staining and TEM. The morphologic changes included spotty necrosis with lymphocyte, monocyte, and neutrophil infiltration, fatty degeneration of hepatocytes with dilatation of rough endoplasmic reticulum and dissociation of ribosomes, as well as degeneration of mitochondria and karyorrhexis.
CONCLUSIONSO(2) inhalation can cause marked liver injury in experimental settings.