Pancreatic Endocrine Tumors: Clinical Manifestations and Predictive Factors Associated with Survival.
- Author:
Woo Hyun PAIK
1
;
Yong Bum YOON
;
Sang Hyub LEE
;
Joo Kyung PARK
;
Sang Myung WOO
;
Ki Young YANG
;
Jeong Kyun SEO
;
Ji Kon RYU
;
Yong Tae KIM
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul, Korea. yyb10604@plaza.snu.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Pancreatic neoplasm;
Islet cell;
Survival;
Prognosis
- MeSH:
Adenoma, Islet Cell/*diagnosis/epidemiology/*mortality;
Adolescent;
Adult;
Aged;
Combined Modality Therapy;
Female;
Follow-Up Studies;
Humans;
Liver Neoplasms/diagnosis/secondary;
Lymph Nodes/pathology;
Male;
Middle Aged;
Multivariate Analysis;
Pancreatic Neoplasms/*diagnosis/epidemiology/*mortality;
Predictive Value of Tests;
Prognosis;
Retrospective Studies;
Survival Rate;
Tomography, X-Ray Computed;
Treatment Outcome
- From:The Korean Journal of Gastroenterology
2008;52(3):171-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Since pancreatic endocrine tumors (PET) are rare and heterogeneous diseases, their survival and prognosis are not well known. Due to recent advances in CT/MRI technology, incidentalomas of the pancreas are detected with increasing frequency. This study presents results of clinical manifestations of PET and predictive factors associated with survival. METHODS: From year 1990 through 2006, medical records of 98 patients (56 men, 42 women) who were diagnosed as PET pathologically at Seoul National University Hospital were reviewed retrospectively. RESULTS: Ages ranged from 17 to 76 years (mean 51.6+/-1.3 years) with a mean follow-up of 3.6+/-0.4 years (range 0-10.1 years). Overall 5-year survival rate was 68.1%, and 5-year survival rate of the patients who had distant metastases at initial diagnosis was 43.9%. Functioning tumors [hazard ratio (HR) 0.229, 95% confidence interval (CI) 0.056-0.943, p=0.041] and lymph node or liver metastases (HR 5.537, 95% CI 2.106-14.555, p<0.001) were the significant prognostic factors associated with survival rate. However, tumor size and pathology showed no significant association with survival. CONCLUSIONS: Because small and pathologically benign nature do not predict good prognosis in PET, aggressive treatment such as curative resection would be considered initially even in the case of incidental PET.
