Usual hyperplasia, atypical hyperplasia and carcinoma-in-situ of breast: a morphologic study.
- Author:
Xiu KAN
1
;
Dan-hua SHEN
;
Bin SHI
;
Jing-sheng HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Breast; pathology; Breast Neoplasms; pathology; Carcinoma in Situ; pathology; Carcinoma, Ductal, Breast; pathology; Carcinoma, Intraductal, Noninfiltrating; pathology; Diagnosis, Differential; Female; Fibroadenoma; pathology; Humans; Hyperplasia; pathology; Middle Aged; Precancerous Conditions; pathology
- From: Chinese Journal of Pathology 2004;33(4):312-315
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the morphologic classification of mammary ductal hyperplasia, and its criteria and the significance in distinguishing atypical hyperplasia from carcinoma-in-situ.
METHODSThe clinicopathologic features of 300 cases of hyperplasia of breast were reviewed. Whole-organ H&E sections were also available in 86 cases of breast carcinoma. The occurrence of atypical hyperplasia in adjacent breast tissue was assessed.
RESULTSFibroadenomatoid changes were typically observed in the 21-30 age groups and atypical hyperplasia occurred more frequently in 40-60 age groups. Amongst the hyperplastic cases, cystic diseases of the breast were noted in only 6%. In contrast, fibroadenomatoid changes were more common (25.4%). Atypical ductal hyperplasia occurred in adjacent breast tissue of 65.1% of the carcinoma cases. The incidence was higher (74.9%) if the main lesion was ductal carcinoma-in-situ.
CONCLUSIONSThere is a close association between atypical hyperplasia and breast carcinoma. It is prudent to distinguish between usual and atypical hyperplasia. Morphologic differentiation between atypical ductal hyperplasia and ductal carcinoma-in-situ may sometimes be difficult.