Genome-wide genetic study of medulloblastoma using allelotype analysis.
- Author:
Xiao-lu YIN
1
;
Chung-Sean PANG
;
Ho-Keung NG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Alleles; Allelic Imbalance; Cerebellar Neoplasms; genetics; Child; Child, Preschool; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; Female; Genotype; Humans; Male; Medulloblastoma; genetics; Microsatellite Repeats; genetics
- From: Chinese Journal of Pathology 2004;33(5):413-415
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate global genetic alterations in medulloblastoma, and to localize critical chromosomal loci with allelic imbalances associated with the development of medulloblastoma.
METHODSA high-resolution genome-wide allelotype analysis, including 384 microsatellite markers, was performed in 12 medulloblastomas.
RESULTSAn average of 238 (62.3%) allelic imbalances were detected on all 39 autosomal arms. Non-random allelic gains or losses were detected on chromosomes 7q (58.3%), 8p (66.7%), 16q (58.3%), 17p (58.3%) and 17q (66.7%). In addition, chromosomal arms with frequencies of allelic imbalances higher than the mean percentage were identified on 3p (33.3%), 3q (33.3%), 4q (41.7%), 7p (33.3%), 8q (41.7%), 10q (41.7%), 13q (33.3%), 14q (33.3%) and 20q (33.3%). No relationship was found between the frequency of allelic imbalances and the clinical outcome of the patients.
CONCLUSIONSA global view of the genetic alterations in medulloblastoma was provided. The allelic imbalances involving chromosomes 7q, 8p, 16q, 17p and 17q may play an important role in the pathogenesis of medulloblastoma.
