Morphologic variants and immunohistochemical features of hepatic angiomyolipoma.
- Author:
Shu-hui ZHANG
1
;
Wen-ming CONG
;
Zhi-hong XIAN
;
Wei-qing WU
;
Hui DONG
;
Meng-chao WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angiomyolipoma; classification; immunology; pathology; Antigens, Neoplasm; analysis; Biomarkers, Tumor; analysis; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Immunohistochemistry; Liver; pathology; Liver Neoplasms; classification; immunology; pathology; Male; Melanoma-Specific Antigens; Middle Aged; Neoplasm Proteins; analysis; Proto-Oncogene Proteins c-kit; analysis
- From: Chinese Journal of Pathology 2004;33(5):437-440
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathological characteristics, immunohistochemical features and differential diagnosis of hepatic angiomyolipoma (AML).
METHODSThe clinicopathological features of hepatic AML were systematically examined in 44 surgically resected tumor specimens, with additional immunohistochemistry study using 10 relevant antibodies.
RESULTSThe tumors were composed of various amounts of three components, i.e. blood vessels, smooth muscle cells and adipose cells. According to the proportions of each of these tissue components, AML was subcategorized into the classical type (n = 13), myomatous type (n = 25), lipomatous type (n = 4), and angiomatous type (n = 2). Myoid cells displayed various morphology, including epithelioid, intermediate (ovoid or short spindle), spindle, oncocytic, and pleomorphic features. Hematopoietic elements were present as minor findings in eight tumors. Immunohistochemically, the tumor cells were strongly positive for HMB45 (44/44, 100%), SMA (38/38, 100%) and CD117 (30/38, 78.9%).
CONCLUSIONSA correct diagnosis of hepatic AML might be difficult due to its various growth patterns and cell types. HMB-45 positivity in the myoid cells is a key feature for hepatic AML. CD117 may be another useful ancillary marker for reaching a definite diagnosis.
