Effection of compositie salviae dropping pill on hyperlipemia patients with phlegm and blood stasis syndrome.
- Author:
Shi-Jun ZHANG
1
;
Ze-Xiong CHENG
;
You-Wu LIN
;
Jian QIN
;
Yong-Hua CHENG
;
Su-Ling LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alanine Transaminase; blood; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; therapeutic use; Female; Humans; Hypercholesterolemia; blood; drug therapy; Hypertriglyceridemia; blood; drug therapy; Interleukin-8; blood; Male; Middle Aged; Phytotherapy; Plants, Medicinal; chemistry; Salvia miltiorrhiza; chemistry; Superoxide Dismutase; blood; gamma-Glutamyltransferase; blood
- From: China Journal of Chinese Materia Medica 2007;32(5):440-443
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of compositie salviae dropping pill (CSDP) on hyperlipemia patients with phlegm and blood stasis syndrome.
METHODHyperlipemia patients were divided randomly into two groups. One group of 40 patients were treated by CSDP, another group of 41 patients were treated by simvastatin. The TC, TG, HDL-C, LDL-C, ApoA and ApoB levels, ALT, r-GT, IL-6, MDA level and SOD activity were determined before and after being treated.
RESULTAfter 3 months treatment, the TC, TG and LDL-C levels were obviously decreased in two groups (P <0.01, P < 0.05), there is no significant difference between the effective rate of two groups. The ALT, r-GT, IL-8 and MDA levels of treatment group were obviously decreased (P < 0.01, P < 0.05), while the ApoA level and SOD activity increased obviously in those patients (P <0.05, P <0.01, respectively). However, the ALT, r-GT, IL-6, MDA, HDL-C, ApoA level and SOD activity had no significant difference after treatment in control group.
CONCLUSIONOur study suggest that CSDP have the function of falling serum lipid level without damaging liver function, its function of protecting liver function might related to its function of improving of anti-oxidation and decreasing of inflammation, the mechanism of CSDP disparting and removing phlem and blood stasis in the processes lipid metabolism need to be studied further.
