Study on alpha-asarone reservoir-type patch.
- Author:
Zheng WU
1
;
Jian-Qing GAO
;
Hai-Liang CHEN
;
Ying HU
;
Wen-Quan LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Acorus; chemistry; Administration, Cutaneous; Anisoles; administration & dosage; isolation & purification; pharmacokinetics; Delayed-Action Preparations; administration & dosage; pharmacokinetics; Ethanol; pharmacology; Humans; Hypromellose Derivatives; In Vitro Techniques; Methylcellulose; analogs & derivatives; chemistry; Myristates; pharmacology; Plants, Medicinal; chemistry; Polyvinyls; chemistry; Skin; drug effects; metabolism; Skin Absorption; drug effects
- From: China Journal of Chinese Materia Medica 2007;32(6):484-487
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare the alpha-asarone reservoir patch and investigate its release and transdermal absorption characteristics in vitro. The efficient enhancers were chosen to improve the drug's permeation rate.
METHODThe alpha-asarone reservoir patch was prepared using 1% hydroxypropyl methylcellulose (HPMC) of ethanol solution as medium and ethylene vinyl acetate (EVA) membrane to control the release of drug. The Franz diffusion cells were used and several permeation enhancers were evaluated. High performance liquid chromatorgraphy (HPLC) was used to determine alpha-asarone's content and permeation rate.
RESULTThe release mechanisms of alpha K-asarone patch in vitro coincided with zero-order kinetic. 30% ethanol cooperates with 1% Isopropyl Myristate (IPM) have the best effect on permeation of the patch. The permeation rate reaches (20.67 +/- 1.33) microg x cm(-2) h(-1).
CONCLUSIONEthanol combined with IPM is good permeation enhancer, which facilitated the permeation of alpha K-asarone to fit the clinical requirements. However, the further studies of the skin's stimulation and bioavailability are needed.
