Effects of 2-n-nonyl-1,3-dioxolane as an enhanceron transdermal absorption of Salvia miltiorrhiza gel.
- Author:
Mei SHA
1
;
Li-Fang YIN
;
Wei XU
;
Yu-Zhi CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Animals; Dioxolanes; administration & dosage; pharmacology; Diterpenes, Abietane; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacokinetics; Female; Gels; In Vitro Techniques; Male; Mice; Phenanthrenes; analysis; Reproducibility of Results; Salvia miltiorrhiza; chemistry; Skin; drug effects; metabolism; Skin Absorption; drug effects
- From: China Journal of Chinese Materia Medica 2007;32(6):487-489
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo choose the most suitable concentration of 2-n-nonyl-1,3-dioxolane as a penetration enhancer in tanshinone gel preparation.
METHODIn vitro, transdermal absorption was studied using improved Frans equipment and rats skin. Tanshinone II A was tested by HPLC.
RESULTThe 4.0% concentration of 2-n-nonyl-1,3-dioxolane enhanced the transdermal absorption significantly in the preparation.
CONCLUSION2-n-nonyl-1,3-dioxolane was a new effective permeaton enhancer.
