Effect of olive antihyperlipidemia capsule on low and high density lipoprotein receptor in rat liver gene expression in hyperlipmia rat liver.
- Author:
Jin-Sheng ZHANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Drugs, Chinese Herbal; isolation & purification; pharmacology; Gene Expression Regulation; drug effects; Hyperlipidemias; genetics; pathology; prevention & control; Hypolipidemic Agents; isolation & purification; pharmacology; Lipoproteins, HDL; genetics; Liver; metabolism; Male; Olea; chemistry; Plants, Medicinal; chemistry; RNA, Messenger; biosynthesis; genetics; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, LDL; genetics; Receptors, Lipoprotein; genetics; Scavenger Receptors, Class B; genetics
- From: China Journal of Chinese Materia Medica 2007;32(6):519-522
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVETo study on the regulatory mechanism of lipid metabolism disorders in the blood fat of hyperlipemia rat model with Olive Antihyperlipidemia capsule, and do systematic observation on the functions of this medicine on low And high density lipoprotein receptor in rat liver gene expression, and then to clarify the mechanism of action of this medicine on treating hyperlipemia.
METHODTo select SD rat as investigated subject. The hyperlipemia rat models were made with feeding high-fat forage and were randomly divided into six groups based on the total cholesterol level at the ratsfasting for 12 hours: group A, B, C, D, E and group F. The samples in the research were collected and analyzed the changes of LDLR/SR-B1 gene expression in rat's liver by RT-PCR.
RESULTOlive Antihyperlipidemia capsule can markedly enhance LDLR/SR-B1 gene expression in rat's liver and finally accomplish the purpose of reducing blood fat. The experiment shows this medicine has the remarkable effect on hyperlipidemia and proved the theoretical system of treating hyperlipemia for curing the liver is correct.
CONCLUSIONOlive Antihyperlipidemia capsule has an applicable value on preventing the cause, enhance LDLR/SR-B1 gene expression in rat's liver and finally accomplish the purpose of reducing blood fat and development of hyperlipemia and its complications.
