Effects of Salvia miltiorrhiza on Chlamydia trachomatis mice of salpingitis.
- Author:
Mu-Kai CHEN
1
;
Ze-Xiong CHEN
;
Jian-De HAN
;
Qi-Man LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chlamydia Infections; complications; drug therapy; microbiology; Chlamydia trachomatis; drug effects; Drugs, Chinese Herbal; isolation & purification; therapeutic use; Fallopian Tube Diseases; etiology; prevention & control; Fallopian Tubes; drug effects; pathology; Female; Fibrosis; Mice; Mice, Inbred C3H; Phytotherapy; Plants, Medicinal; chemistry; Random Allocation; Salpingitis; complications; drug therapy; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(6):523-525
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Salvia miltiorrhiza on treatment of Chlamydia trachomatis salpingitis (CTS) and fibrosis.
METHODA mouse model for CTS was estahlished in C3H/He by intravaginal inoculation. after 3 weeks mice were randomly divided into 3 groups. Only Azithromyxin was given orally, Azithromyxin and early S. miltiorrhiza given, or Azithromyxin and later S. miltiorrhiza given. After 10 weeks, observe the change of oviduct of mice, observe the histopathologic change and analysis collagen histochemical index.
RESULT3 Treatment groups induce tubal occlusion and hydrosalpinx decreased and the collagen histochemical index decreased significantly than those of no treatment given (P < 0.05). Early S. miltiorrhiza given group induce tubal occlusion and hydrosalpinx decreased and the collagen histochemical index decreased significantly than only Azithromyxin group or later S. miltiorrhiza given group (P <0.05).
CONCLUSIONWhen we treat CTS genital infection with Azithromyxin, if we can give S. miltiorrhiza treatment as early as possible, it may decrease tubal occlusion and hydrosalpinx. significantly inhibit fibrosis maybe one of its pharmacologic mechanismin.
