Shengdi injection on rat model of lung inflammation induced by lipopolysaccharides.
- Author:
Li LIU
1
;
Lan TANG
;
De-Sheng XU
;
Hui-Li XIA
;
Qiang-Min XIE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents, Non-Steroidal; administration & dosage; isolation & purification; pharmacology; Bronchoalveolar Lavage Fluid; chemistry; Cytokines; secretion; Disease Models, Animal; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Injections, Intravenous; Leukocyte Count; Lipopolysaccharides; Lung; drug effects; metabolism; pathology; Male; Neutrophils; drug effects; pathology; Peroxidase; metabolism; Plant Roots; chemistry; Plants, Medicinal; chemistry; Pneumonia; chemically induced; metabolism; prevention & control; Random Allocation; Rats; Rats, Sprague-Dawley; Rehmannia; chemistry; Superoxides; metabolism; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2007;32(6):526-528
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Shengdi injection on rat model of lung inflammation.
METHODThe rat model was established by intratrachea instillation of lipopolysaccharides (LPS). The total and different white blood cell counts in bronchoalvoelar lavage fluid (BALF) were performed and the level of tumor necrosis factor-alpha (TNF-alpha), superoxide anion radical (O2-) and myeloperoxidase (MPO) was measured, as well as pathologic change of pulmonary tissue was tested.
RESULTShengdi injection could depress the increasing of the amount of total white blood cells and neutrophils and inhibit the increasing of TNF-alpha, O2-, MPO caused by LPS, as well as relieve the pathologic change including Neutrophils infiltrating and mucous edema in tracheae after intravenous administration. While it did not show the effect on monocyte, and histological lesion of the lung tissue.
CONCLUSIONShengdi injection shows some anti-inflammatory effect in rat lung induced by LPS and it can be concluded tentatively that anti-inflammatory, inhibiting the release of cytokine and inflammatory medium, and antioxidation are some of the mechanism of its effect on COPD.
