Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC.
- Author:
Wei LIU
1
;
Hong-Jie WANG
;
Nan SI
;
Bao-Lin BIAN
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; analysis; chemistry; Benzylisoquinolines; analysis; chemistry; Chromatography, High Pressure Liquid; methods; Isoquinolines; analysis; chemistry; Microspheres; Nelumbo; chemistry; Particle Size; Phenols; analysis; chemistry; Plants, Medicinal; chemistry; Polyethylene Glycols; chemistry; Quality Control; Seeds; chemistry; Solubility; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2007;32(7):581-584
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the optimum technical parameters through controlling the different factors and the content of Dripping Pill.
METHODTime of dissolution, spherical degree and pill weight as parameters, the influential factors were investigated by orthogonal test and then to determine the content of liensinine, isoliensinine, neferine in plumula nelumbinis Alkaloid Dripping Pill.
RESULTThe optimum condition: 75% PEG4000 as matrix, methyl-silicon oil as refrigerant, 4 cm dripping distance, 10 degrees C refrigerant, 30 drippings per minute.
CONCLUSIONThe good quality pills can be produced through this process and the HPLC determination method is simple, reliable and can be used in the quality control of plumula nelumbinis Alkaloid Dripping Pill.
